Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | USP1 | O94782 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5069859 | 0.81 | PTGS2 (0.72) | PTGS2PTGS1 | |
| SCHEMBL27421541 | 0.74 | PTGS2 (0.59) | PTGS2PTGS1 | |
| SCHEMBL8896836 | 0.74 | PTGS2 (0.53) | PTGS2PTGS1 | |
| SCHEMBL8346351 | 0.73 | PTGS2 (0.50) | PTGS2PTGS1USP1PDE2APDE10A | |
| SCHEMBL8346344 | 0.72 | PTGS2 (0.55) | PTGS2PTGS1USP1PKM | |
| SCHEMBL5594051 | 0.71 | PTGS2 (1.00) | PTGS2PTGS1 | |
| Sulfamide SCHEMBL4639044 | 0.71 | PTGS2 (0.81) | PTGS2PTGS1 | |
| SCHEMBL5069869 | 0.71 | PTGS2 (0.66) | PTGS2PTGS1 | |
| SCHEMBL215052 | 0.70 | PTGS2 (1.00) | PTGS2PTGS1 | |
| Benzenesulfonamide SCHEMBL7048970 | 0.68 | PTGS2 (0.62) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997038986-A1 | SUBSTITUTED BENZENESULFONAMIDE DERIVATIVES AS PRODRUGS OF COX-2 INHIBITORS | G.D. SEARLE & CO. (US) | 1997-10-23 | — | — | WO | disclosed |