Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.53 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8905206 | 0.83 | PTGS2 (0.53) | PTGS2PTGS1 | |
| SCHEMBL5069858 | 0.79 | PTGS2 (0.72) | PTGS2PTGS1 | |
| SCHEMBL8894968 | 0.74 | PTGS2 (0.55) | PTGS2PTGS1 | |
| SCHEMBL27444815 | 0.73 | PTGS2 (0.59) | PTGS2PTGS1 | |
| SCHEMBL5071016 | 0.71 | PTGS2 (0.66) | PTGS2PTGS1 | |
| SCHEMBL8346615 | 0.70 | PTGS2 (0.50) | PTGS2PTGS1 | |
| SCHEMBL8348990 | 0.70 | PTGS2 (0.54) | PTGS2PTGS1SLC22A12 | |
| SCHEMBL3246331 | 0.69 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL212333 | 0.68 | PTGS2 (1.00) | PTGS2PTGS1 | |
| Sulfamide SCHEMBL4638575 | 0.68 | PTGS2 (0.80) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997038986-A1 | SUBSTITUTED BENZENESULFONAMIDE DERIVATIVES AS PRODRUGS OF COX-2 INHIBITORS | G.D. SEARLE & CO. (US) | 1997-10-23 | — | — | WO | disclosed |