Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 12/20 | 0.50 |
| ▸ | RXRG | P48443 | 9/20 | 0.50 |
| ▸ | RXRB | P28702 | 8/20 | 0.50 |
| ▸ | RARA | P10276 | 6/20 | 0.50 |
| ▸ | RARB | P10826 | 6/20 | 0.50 |
| ▸ | RARG | P13631 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8895750 | 0.85 | RXRA (0.68) | RXRARXRGRXRBRARARARB | |
| SCHEMBL8015924 | 0.84 | RXRA (0.71) | RXRARXRGRXRBRARARARB | |
| SCHEMBL8896356 | 0.83 | RARB (0.53) | RXRARXRGRXRBRARARARB | |
| SCHEMBL9551743 | 0.79 | RARA (0.74) | RXRARXRGRXRBRARARARB | |
| SCHEMBL8017935 | 0.77 | RXRA (0.74) | RXRARXRGRXRBRARARARB | |
| SCHEMBL6890269 | 0.77 | RXRA (0.70) | RXRARXRGRXRBRARARARB | |
| SCHEMBL3819796 | 0.76 | RARB (0.60) | RXRARXRGRXRBRARARARB | |
| SCHEMBL8005372 | 0.76 | RXRA (0.56) | RXRARXRGRXRBRARARARB | |
| SCHEMBL9551786 | 0.76 | RARB (0.63) | RXRARXRGRXRBRARARARB | |
| SCHEMBL9551782 | 0.75 | RARB (0.71) | RXRARXRGRXRBRARARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5672710-A | SPECIFIC AGONISTS FOR THE RXR RETINOID RECEPTOR RATHER THAN THE RAR ONE; SIDE EFFECT REDUCTION; SKIN AND NERVOUS SYTEM DISORDERS; ANTICARCINOGENIC AGENTS; VISION DEFECTS | ALLERGAN (US) | 1997-09-30 | — | — | US | disclosed |
| WO-1997016422-A1 | SULFIDES, SULFOXIDES AND SULFONES DISUBSTITUTED WITH A TETRAHYDRONAPHTHALENYL, CHROMANYL, THIOCHROMANYL OR TETRAHYDROQUINOLINYL AND SUBSTITUTED PHENYL OR HETEROARYL GROUP, HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN (US) | 1997-05-09 | — | — | WO | disclosed |