Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NCS1 | P62166 | 1/20 | 0.44 |
| ▸ | PLCG2 | P16885 | 1/20 | 0.44 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMO | Q99835 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 4/20 | 0.42 |
| ▸ | USP8 | P40818 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7901407 | 0.89 | NPC1 (0.55) | NPC1RAB9APLCG2IMPDH2MEN1 | |
| SCHEMBL8894553 | 0.89 | NPC1 (0.50) | NPC1RAB9APLCG2IMPDH2MEN1 | |
| SCHEMBL7894112 | 0.88 | NPC1 (0.52) | NPC1RAB9APLCG2IMPDH2MEN1 | |
| Water SCHEMBL9411708 | 0.88 | NPC1 (0.49) | NPC1RAB9APLCG2IMPDH2MEN1 | |
| Hydrochloric Acid SCHEMBL8894458 | 0.87 | NPC1 (0.48) | NPC1RAB9APLCG2IMPDH2MEN1 | |
| SCHEMBL7899852 | 0.86 | NPC1 (0.47) | NPC1RAB9APLCG2IMPDH2MEN1 | |
| SCHEMBL8893820 | 0.83 | NPC1 (0.47) | NPC1RAB9APLCG2IMPDH2MEN1 | |
| SCHEMBL8896967 | 0.83 | NPC1 (0.47) | NPC1RAB9APLCG2IMPDH2MEN1 | |
| SCHEMBL7894249 | 0.82 | MAPT (0.57) | NPC1RAB9APLCG2IMPDH2MEN1 | |
| SCHEMBL27426133 | 0.81 | NPC1 (0.50) | NPC1RAB9APLCG2IMPDH2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656648-A | TREATMENT OF PATHOLOGIES NECESSITATING STIMULATION OF CHOLECYSTOKININ-A RECEPTORS BY TOTAL OR PARTIAL AGONIST EFFECT | SANOFI (FR) | 1997-08-12 | — | — | US | disclosed |
| CN-1107158-A | Polysubstituted 2-amino-thiazole derivatives | SANOFI ELF (FR) | 1995-08-23 | — | — | CN | disclosed |
| EP-0611766-A1 | Polysubstituted 2-amido thiazoles derivatives, process for their preparation, pharmaceutical compositions and utilization for the preparation of a medicament | SANOFI (FR) | 1994-08-24 | — | — | EP | disclosed |