Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | PLCG2 | P16885 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.46 |
| ▸ | SMO | Q99835 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8894553 | 0.92 | NPC1 (0.50) | NPC1RAB9APLCG2ADORA3KMT2A | |
| SCHEMBL7894112 | 0.92 | NPC1 (0.52) | NPC1RAB9APLCG2ADORA3KMT2A | |
| Water SCHEMBL9411708 | 0.91 | NPC1 (0.49) | NPC1RAB9APLCG2ADORA3KMT2A | |
| Hydrochloric Acid SCHEMBL8894458 | 0.90 | NPC1 (0.48) | NPC1RAB9APLCG2ADORA3KMT2A | |
| SCHEMBL7899852 | 0.89 | NPC1 (0.47) | NPC1RAB9APLCG2ADORA3KMT2A | |
| SCHEMBL8895413 | 0.89 | NPC1 (0.47) | NPC1RAB9APLCG2ADORA3KMT2A | |
| SCHEMBL8893820 | 0.87 | NPC1 (0.47) | NPC1RAB9APLCG2ADORA3KMT2A | |
| SCHEMBL8896967 | 0.87 | NPC1 (0.47) | NPC1RAB9APLCG2ADORA3KMT2A | |
| SCHEMBL7894249 | 0.86 | MAPT (0.57) | NPC1RAB9APLCG2ADORA3KMT2A | |
| SCHEMBL7894108 | 0.86 | ADORA3 (0.66) | NPC1RAB9APLCG2ADORA3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0432040-B2 | Heterocyclic derivatives of acylaminothiazole, their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1997-12-17 | — | — | EP | claimed |
| US-5189049-A | Cholecystokinin and gastrin inhibitors | SANOFI (FR) | 1993-02-23 | — | — | US | claimed |
| US-RE37094-E1 | Heterocyclic substituted acylaminothiazoles, their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 2001-03-13 | — | — | US | disclosed |
| US-5189049-A | Cholecystokinin and gastrin inhibitors | SANOFI (FR) | 1993-02-23 | — | — | US | disclosed |