Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 6/20 | 0.43 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | HLA-DRB1 | P01911 | 1/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 1/20 | 0.41 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.40 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.40 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.40 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.40 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.40 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1006593 | 0.90 | PSEN1 (0.54) | BACE1APPPSEN1PSEN2APH1B | |
| SCHEMBL8893248 | 0.90 | PSEN1 (0.54) | BACE1APPPSEN1PSEN2APH1B | |
| SCHEMBL8894263 | 0.87 | CTSS (0.47) | CTSBCTSLCTSSRENPSMB11 | |
| SCHEMBL8893226 | 0.87 | PSEN1 (0.51) | BACE1APPPSEN1PSEN2APH1B | |
| SCHEMBL9397295 | 0.82 | PSEN1 (0.46) | BACE1APPPSEN1PSEN2APH1B | |
| SCHEMBL4180459 | 0.82 | PSEN1 (0.56) | BACE1APPPSEN1PSEN2APH1B | |
| SCHEMBL4180455 | 0.82 | PSEN1 (0.56) | BACE1APPPSEN1PSEN2APH1B | |
| SCHEMBL7388307 | 0.81 | CTSK (0.51) | CTSBCTSLCTSSCTSD | |
| SCHEMBL7514990 | 0.81 | CTSS (0.51) | CTSBCTSLCTSSPSMB5 | |
| SCHEMBL14389899 | 0.80 | PSMB8 (0.44) | CTSBBACE1CTSDRENPSMB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643878-A | TREATMENT OF RETROVIRAL DISEASES LIKE AIDS | CIBA-GEIGY CORPORATION (US) | 1997-07-01 | — | — | US | disclosed |