SCHEMBL8896538

SCHEMBL8896538

CC(=O)Oc1cc(OCc2ccccc2)ccc1C

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 1/20 0.63
MAOB P27338 4/20 0.59
MAPK1 P28482 2/20 0.50
CASP3 P42574 1/20 0.50
SENP8 Q96LD8 1/20 0.50
SENP7 Q9BQF6 1/20 0.50
SENP6 Q9GZR1 1/20 0.50
MAPT P10636 1/20 0.50
MRGPRX4 Q96LA9 1/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
ALDH1A1 P00352 1/20 0.49
HTT P42858 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
NR4A2 P43354 2/20 0.49
SRD5A2 P31213 1/20 0.49
NR4A1 P22736 1/20 0.49
NR4A3 Q92570 1/20 0.49
NPC1 O15118 1/20 0.48
RAB9A P51151 1/20 0.48
ACHE P22303 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4847906 0.89 PTPN1 (0.63) PTPN1MAOBCASP3SENP8SENP7
SCHEMBL4363943 0.87 MAOB (0.57) PTPN1MAOBCASP3SENP8SENP7
SCHEMBL8000403 0.87 MAOB (0.57) PTPN1MAOBCASP3SENP8SENP7
SCHEMBL6195352 0.84 MAOB (0.55) PTPN1MAOBMAPTMRGPRX4SMN1; SMN2
SCHEMBL19712578 0.84 MAOB (0.55) PTPN1MAOBMAPTSMN1; SMN2ALDH1A1
SCHEMBL28886867 0.84 MAOB (0.51) PTPN1MAOBMAPK1CASP3SENP8
SCHEMBL19286354 0.83 ALOX5 (0.58) MAOBMAPK1CASP3SENP8SENP7
SCHEMBL588979 0.82 MAOB (0.76) MAOBCASP3SENP8SENP7SENP6
SCHEMBL4840332 0.82 FFAR1 (0.55) PTPN1MAOBMRGPRX4
SCHEMBL12987826 0.82 MAOB (0.55) PTPN1MAOBMRGPRX4SMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0712493-A4 A METHOD FOR PREPARING AND SELECTING PHARMACEUTICALLY USEFUL NON-PEPTIDE COMPOUNDS FROM A STRUCTURALLY DIVERSE UNIVERSAL LIBRARY SPHINX PHARMA CORP (US) 1997-01-15 EP disclosed
EP-0712493-A1 A METHOD FOR PREPARING AND SELECTING PHARMACEUTICALLY USEFUL NON-PEPTIDE COMPOUNDS FROM A STRUCTURALLY DIVERSE UNIVERSAL LIBRARY SPHINX PHARMACEUTICALS CORPORATION (US) 1996-05-22 EP disclosed
WO-1995004277-A1 A METHOD FOR PREPARING AND SELECTING PHARMACEUTICALLY USEFUL NON-PEPTIDE COMPOUNDS FROM A STRUCTURALLY DIVERSE UNIVERSAL LIBRARY SPHINX PHARMACEUTICALS CORPORATION (US) 1995-02-09 WO disclosed