SCHEMBL8896574

SCHEMBL8896574

COC(=O)CCCc1ccc(C(CCc2ccccc2C)NS(=O)(=O)c2ccc(Cl)cc2)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 1/20 0.45
TBXAS1 P24557 4/20 0.40
TBXA2R P21731 3/20 0.40
ALDH1A1 P00352 3/20 0.39
ATM Q13315 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
CCR9 P51686 1/20 0.39
MMP2 P08253 1/20 0.38
MMP9 P14780 1/20 0.38
TP53 P04637 1/20 0.38
GAA P10253 1/20 0.38
LMNA P02545 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
MAPK1 P28482 1/20 0.38
FLT1 P17948 1/20 0.38
FLT4 P35916 1/20 0.38
KDR P35968 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8897043 0.92 ALDH1A1 (0.46) UTS2RTBXAS1TBXA2RALDH1A1ATM
SCHEMBL8897066 0.92 UTS2R (0.49) UTS2RTBXAS1TBXA2RALDH1A1ATM
SCHEMBL8898306 0.91 TBXAS1 (0.47) UTS2RTBXAS1TBXA2RALDH1A1ATM
SCHEMBL8895014 0.90 UTS2R (0.56) UTS2RTBXAS1TBXA2RALDH1A1ATM
SCHEMBL8895038 0.89 UTS2R (0.45) UTS2RTBXAS1TBXA2RALDH1A1CCR9
SCHEMBL8896098 0.88 UTS2R (0.46) UTS2RTBXAS1TBXA2RALDH1A1ATM
SCHEMBL8896351 0.88 ALDH1A1 (0.46) UTS2RTBXAS1TBXA2RALDH1A1ATM
SCHEMBL8895823 0.87 UTS2R (0.47) UTS2RTBXAS1TBXA2RALDH1A1L3MBTL1
SCHEMBL8898580 0.87 ALDH1A1 (0.49) UTS2RALDH1A1MMP2MMP9LMNA
SCHEMBL8895435 0.87 UTS2R (0.45) UTS2RTBXAS1TBXA2RALDH1A1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5597848-A PLATELET AGGREGATION INHIBITORS, ANTITHROMBOTIC AGENTS, ANTIASTHMATIC AGENTS, ANTIALLERGIC AGENTS HOKURIKU SEIYAKU CO., LTD. (JP) 1997-01-28 US disclosed
EP-0663392-A1 BENZENESULFONAMIDE DERIVATIVE AND USE THEREOF HOKURIKU SEIYAKU CO., LTD. (JP) 1995-07-19 EP disclosed