Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | BACE1 | P56817 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2985757 | 0.87 | SMN1; SMN2 (0.75) | SMN1; SMN2SIGMAR1ALDH1A1TSHROPRM1 | |
| SCHEMBL7706443 | 0.86 | SMN1; SMN2 (0.63) | SMN1; SMN2SIGMAR1ACHEBACE1ALDH1A1 | |
| SCHEMBL16876678 | 0.85 | SMN1; SMN2 (0.56) | SMN1; SMN2GAASIGMAR1OPRM1MMP1 | |
| SCHEMBL654710 | 0.85 | SMN1; SMN2 (0.64) | SMN1; SMN2SIGMAR1ACHEBACE1ALDH1A1 | |
| SCHEMBL5561697 | 0.84 | SMN1; SMN2 (0.63) | SMN1; SMN2GAASIGMAR1ACHEBACE1 | |
| SCHEMBL16876701 | 0.84 | SMN1; SMN2 (0.63) | SMN1; SMN2SIGMAR1ALDH1A1CYP2D6OPRM1 | |
| SCHEMBL16876699 | 0.84 | SMN1; SMN2 (0.63) | SMN1; SMN2SIGMAR1ALDH1A1CYP2D6TSHR | |
| SCHEMBL4125351 | 0.83 | SIGMAR1 (0.56) | SMN1; SMN2SIGMAR1ALDH1A1CYP2D6TSHR | |
| SCHEMBL11565487 | 0.80 | SIGMAR1 (0.58) | SIGMAR1ACHEBACE1ALDH1A1CYP2D6 | |
| SCHEMBL16876707 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2SIGMAR1OPRM1KCNH2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610142-A | Bradykinin antagonist pseudopeptide derivatives of substituted 4-keto-1,3,8-triazaspiro[4.5]decan-3-alkanoic acids | SCIOS INC. (US) | 1997-03-11 | — | — | US | disclosed |