Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | NPFFR1 | Q9GZQ6 | 4/20 | 0.54 |
| ▸ | NPFFR2 | Q9Y5X5 | 4/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | BACE1 | P56817 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MMP1 | P03956 | 1/20 | 0.52 |
| ▸ | MMP9 | P14780 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 1/20 | 0.52 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11564980 | 0.87 | NPFFR1 (0.65) | SIGMAR1ALDH1A1NPFFR1NPFFR2TSHR | |
| SCHEMBL3178014 | 0.87 | NPFFR1 (0.67) | SIGMAR1ALDH1A1NPFFR1NPFFR2TSHR | |
| Hydrochloric Acid SCHEMBL6123389 | 0.87 | NPFFR1 (0.67) | SIGMAR1ALDH1A1NPFFR1NPFFR2TSHR | |
| SCHEMBL11565877 | 0.86 | NPFFR1 (0.57) | SIGMAR1ALDH1A1NPFFR1NPFFR2ACHE | |
| SCHEMBL11566400 | 0.84 | NPFFR1 (0.57) | SIGMAR1ALDH1A1NPFFR1NPFFR2ACHE | |
| SCHEMBL11568366 | 0.82 | CYP2D6 (0.58) | SIGMAR1ALDH1A1NPFFR1NPFFR2ACHE | |
| SCHEMBL11559495 | 0.81 | CYP2D6 (0.57) | SIGMAR1ALDH1A1NPFFR1NPFFR2ACHE | |
| SCHEMBL8893210 | 0.80 | ALDH1A1 (0.61) | SIGMAR1ALDH1A1NPFFR1NPFFR2ACHE | |
| Hydrochloric Acid SCHEMBL11565355 | 0.80 | NPFFR1 (0.58) | SIGMAR1NPFFR1NPFFR2CYP2D6OPRM1 | |
| Hydrochloric Acid SCHEMBL27922841 | 0.80 | NPFFR1 (0.58) | SIGMAR1NPFFR1NPFFR2CYP2D6OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4179569-A | ANALGESIC INTERMEDIATES | JANSSEN PHARMACEUTICA N.V. (BE) | 1979-12-18 | — | — | US | disclosed |