SCHEMBL8896743

SCHEMBL8896743

CC(C)OC(=O)N(C(C)c1cc2cc(F)ccc2o1)[C@H](C(N)=O)C(C)C

nearest known ligand 0.42

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.41
MAOA P21397 3/20 0.36
MAOB P27338 3/20 0.36
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA9 Q16790 1/20 0.35
CHRNA7 P36544 1/20 0.34
MAPT P10636 2/20 0.33
PLAU P00749 1/20 0.32
TAS1R3 Q7RTX0 1/20 0.31
TAS1R1 Q7RTX1 1/20 0.31
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
APP P05067 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8896867 0.87 ALOX5 (0.58) ALOX5MAOBCA12CA1CA2
SCHEMBL8896175 0.77 ALOX5 (0.40) ALOX5CHRNA7CYP1A2
SCHEMBL8060779 0.77 ALOX5 (0.59) ALOX5MAOBCA12CA1CA2
SCHEMBL8896191 0.74 ALOX5 (0.53) ALOX5MAOBTAS1R3TAS1R1KDM4E
SCHEMBL10480284 0.74 ALOX5 (0.71) ALOX5
SCHEMBL8896909 0.73 ALOX5 (0.54) ALOX5MAOBTAS1R3TAS1R1KDM4E
SCHEMBL8500496 0.71 MAOA (0.42) ALOX5MAOAMAOBCA12CA1
SCHEMBL8069842 0.70 NPC1 (0.36) MAPTKDM4EALDH1A1CYP1A2CYP2C9
SCHEMBL6332567 0.70 ALOX5 (0.54) ALOX5MAOAMAOBCA12CA1
SCHEMBL8896748 0.68 MAOB (0.37) MAOBTAS1R3TAS1R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0587110-B1 Condensed heterocyclic derivatives and agricultural or horticultural fungicides containing the same KUMIAI CHEMICAL INDUSTRY CO (JP) 1997-12-17 EP claimed
EP-0587110-B1 Condensed heterocyclic derivatives and agricultural or horticultural fungicides containing the same KUMIAI CHEMICAL INDUSTRY CO (JP) 1997-12-17 EP disclosed