Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 3/20 | 0.37 |
| ▸ | MMP3 | P08254 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8897311 | 1.00 | REN (0.38) | RENNPC1MAPTRAB9AMMP2 | |
| SCHEMBL7358203 | 0.92 | CTSD (0.39) | RENMMP2MMP3 | |
| SCHEMBL7358269 | 0.89 | CYP3A4 (0.39) | RENALDH1A1 | |
| SCHEMBL9240630 | 0.86 | NPC1 (0.37) | RENNPC1MAPTRAB9AMMP2 | |
| SCHEMBL7395360 | 0.86 | NPC1 (0.37) | RENNPC1MAPTRAB9AMMP2 | |
| SCHEMBL7357186 | 0.86 | NPC1 (0.37) | RENNPC1MAPTRAB9AMMP2 | |
| SCHEMBL7424741 | 0.83 | HTT (0.46) | RENBCHE | |
| SCHEMBL7424747 | 0.83 | HTT (0.46) | RENBCHE | |
| SCHEMBL7353667 | 0.82 | MEN1 (0.41) | RENMAPTALDH1A1 | |
| SCHEMBL8899924 | 0.81 | BACE1 (0.36) | RENNPC1MAPTRAB9AMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614522-A | SULFONAMIDE AND UREA-CONTAINING HYDROXYETHYLAMINE COMPOUNDS | G.D. SEARLE & CO. (US) | 1997-03-25 | — | — | US | disclosed |