Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of (+/-)Nicotine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 known ✓ | P17787 | 4/20 | 0.97 |
| ▸ | CHRNA4 known ✓ | P43681 | 4/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.97 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.97 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.97 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.97 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.97 |
| ▸ | LMNA | P02545 | 1/20 | 0.97 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.97 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.97 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.97 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.97 |
| ▸ | HTR3B | O95264 | 1/20 | 0.97 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.97 |
| ▸ | CHRNG | P07510 | 1/20 | 0.97 |
| ▸ | MAPT | P10636 | 1/20 | 0.97 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.97 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.97 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.97 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (+/-)Nicotine SCHEMBL29527056 | 1.00 | ALDH1A1 (0.97) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL28090760 | 1.00 | ALDH1A1 (0.97) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL1086290 | 1.00 | ALDH1A1 (0.97) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL28107240 | 0.98 | ALDH1A1 (0.94) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL28285656 | 0.98 | ALDH1A1 (0.94) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL28285655 | 0.98 | ALDH1A1 (0.94) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL2599622 | 0.98 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL797620 | 0.98 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL10909351 | 0.98 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL10909353 | 0.98 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118483336-A | Method for simultaneously detecting neurotransmitter and nicotine and metabolites thereof in sample | 北京生命科技研究院有限公司 | 2024-08-13 | — | — | CN | claimed |
| CN-109362738-A | A kind of nicotine amino-oligosaccharide medicament and method for preventing and treating tobacco pest and disease damage | 潍坊奥丰作物病害防治有限公司 | 2019-02-22 | — | — | CN | claimed |
| CN-106011059-A | Method for enrichment culture of high-purity CD56 positive cells | 福州市传染病医院 | 2016-10-12 | — | — | CN | claimed |
| CN-122016988-A | Simultaneous detection method for nicotine, metabolites, neurotransmitters and lipids in brain tissue sample | 国家烟草质量监督检验中心 | 2026-05-12 | — | — | CN | disclosed |
| CN-118483336-A | Method for simultaneously detecting neurotransmitter and nicotine and metabolites thereof in sample | 北京生命科技研究院有限公司 | 2024-08-13 | — | — | CN | disclosed |
| WO-2024066095-A1 | NICOTINE SALT AND ATOMIZED LIQUID THEREOF, VAPE CARTRIDGE AND USE | 深圳市真味生物科技有限公司 | 2024-04-04 | — | — | WO | disclosed |
| CN-117263857-A | Preparation of nikko-brazil nitrogen oxide impurity | 浙江美诺华药物化学有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-117263857-A | Preparation of nikko-brazil nitrogen oxide impurity | 浙江美诺华药物化学有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-116268525-A | Nicotine salt, atomized liquid, cartridge and application thereof | 深圳市真味生物科技有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-109362738-A | A kind of nicotine amino-oligosaccharide medicament and method for preventing and treating tobacco pest and disease damage | 潍坊奥丰作物病害防治有限公司 | 2019-02-22 | — | — | CN | disclosed |
| CN-106418650-B | A kind of sugared nitrogen base regulation and control method of papermaking-method reconstituted tobaccos extract solution | 湖北中烟工业有限责任公司 | 2017-08-29 | — | — | CN | disclosed |
| CN-106011059-A | Method for enrichment culture of high-purity CD56 positive cells | 福州市传染病医院 | 2016-10-12 | — | — | CN | disclosed |
| CN-106011059-A | Method for enrichment culture of high-purity CD56 positive cells | 福州市传染病医院 | 2016-10-12 | — | — | CN | disclosed |
| CN-101260387-A | Tobacco leaf on-line alcoholized enzyme preparation and preparation method thereof | YUNNAN WONFINE BIOTECHNOLOGY C (CN) | 2008-09-10 | — | — | CN | disclosed |
| CN-101254027-A | Producing method of novel tobacco fermenting enzyme preparations | WEI HAN (CN) | 2008-09-03 | — | — | CN | disclosed |
| CN-101144073-A | Method for producing tobacco leaf fermenting enzyme preparation | XIE YONG HAN WEI CHEN YINGKUN (CN) | 2008-03-19 | — | — | CN | disclosed |
| CN-101144074-A | Method for producing tobacco leaf fermenting enzyme preparation | YUNNAN WANFANG BIOTECHNOLOGY C (CN) | 2008-03-19 | — | — | CN | disclosed |
| CN-1167787-A | Fragrance far intrared paint for flue-cured tobacco | GAO CHENGXUAN (CN) | 1997-12-17 | — | — | CN | disclosed |
| US-5691365-A | Nicotinic receptor antagonists in the treatment of neuropharmacological disorders | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 1997-11-25 | — | — | US | disclosed |
| CN-1077096-A | Burley bud sweet paste and using method thereof | BURLEY REROASTING FACTORY JIAN (CN) | 1993-10-13 | — | — | CN | disclosed |