Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nicotine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 known ✓ | P17787 | 4/20 | 0.97 |
| ▸ | CHRNA4 known ✓ | P43681 | 4/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.97 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.97 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.97 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.97 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.97 |
| ▸ | LMNA | P02545 | 1/20 | 0.97 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.97 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.97 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.97 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.97 |
| ▸ | HTR3B | O95264 | 1/20 | 0.97 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.97 |
| ▸ | CHRNG | P07510 | 1/20 | 0.97 |
| ▸ | MAPT | P10636 | 1/20 | 0.97 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.97 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.97 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.97 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (+/-)Nicotine SCHEMBL29527056 | 1.00 | ALDH1A1 (0.97) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL28090760 | 1.00 | ALDH1A1 (0.97) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL8897508 | 1.00 | ALDH1A1 (0.97) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL28107240 | 0.98 | ALDH1A1 (0.94) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL28285656 | 0.98 | ALDH1A1 (0.94) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL28285655 | 0.98 | ALDH1A1 (0.94) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL2599622 | 0.98 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL797620 | 0.98 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL10909351 | 0.98 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL10909353 | 0.98 | ALDH1A1 (1.00) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110384700-A | A kind of composition synthesizing nicotine | 云南喜科科技有限公司 | 2019-10-29 | — | — | CN | claimed |
| CN-108778240-A | Skin care product for baby | 阿甫夏洛穆·夫马修 | 2018-11-09 | — | — | CN | claimed |
| CN-107197938-A | A kind of method for suppressing potato sprout | 蚌埠市乔峰农业蔬菜专业合作社 | 2017-09-26 | — | — | CN | claimed |
| CN-105284508-A | Cultivating method for rice with rich iron nutrition | CHEN ZUQING | 2016-02-03 | — | — | CN | claimed |
| CN-103190549-A | Agrotis ypsilon feed and breeding method thereof | UNIV SOUTHWEST | 2013-07-10 | — | — | CN | claimed |
| US-20240066019-A1 | COMPOSITION FOR ENHANCING MITOCHONDRIAL FUNCTION | MITOCHOLINE LTD (GB) | 2024-02-29 | — | — | US | disclosed |
| US-11826362-B2 | Composition for enhancing mitochondrial function | MITOCHOLINE LTD (GB) | 2023-11-28 | — | — | US | disclosed |
| WO-2023190598-A1 | COMPOSITION | アース製薬株式会社 | 2023-10-05 | — | — | WO | disclosed |
| US-20230181557-A1 | COMPOSITIONS FOR SYNERGISTICALLY ENHANCING MITOCHONDRIAL FUNCTION | Mitocholine Ltd. (GB) | 2023-06-15 | — | — | US | disclosed |
| US-20230087789-A1 | COMPOSITION FOR ENHANCING MITOCHONDRIAL FUNCTION | Mitocholine Ltd. (GB) | 2023-03-23 | — | — | US | disclosed |
| US-11571415-B2 | Composition for enhancing mitochondrial function | Mitocholine Ltd. (GB) | 2023-02-07 | — | — | US | disclosed |
| CN-113519534-B | Insecticidal composition containing brofenbendiamide and flonicamid and application thereof | 上海明德立达生物科技有限公司 | 2022-02-25 | — | — | CN | disclosed |
| US-6135121-A | CURED YELLOW TOBACCO FREE OF ORGANIC LIQUIDS FOR EXTRACTION OF EXPANDED ORGANIC MATERIALS AND HAVING A COLLECTIVE CONTENT OF N'-NITROSO-NORNICOTINE, 4-(N-NITROSOMETHYLAMINO)-1-(3-PYRIDYL)-1-BUTANONE, | REGENT COURT TECHNOLOGIES (US) | 2000-10-24 | — | — | US | disclosed |
| WO-2000015056-A1 | IMPROVED METHOD OF TREATING TOBACCO TO REDUCE NITROSAMINE CONTENT, AND PRODUCTS PRODUCED THEREBY | STAR SCIENTIFIC, INC. (US) | 2000-03-23 | — | — | WO | disclosed |
| EP-0967898-A4 | METHOD OF TREATING TOBACCO TO REDUCE NITROSAMINE CONTENT, AND PRODUCTS PRODUCED THEREBY | WILLIAMS JONNIE R (US) | 2000-01-05 | — | — | EP | disclosed |
| EP-0967898-A1 | METHOD OF TREATING TOBACCO TO REDUCE NITROSAMINE CONTENT, AND PRODUCTS PRODUCED THEREBY | Williams, Jonnie R. (US) | 2000-01-05 | — | — | EP | disclosed |
| CN-1231583-A | Method for treating tobacco to reduce nitrosamine content and products produced thereby | WILLIAMS JONNIE R (US) | 1999-10-13 | — | — | CN | disclosed |
| WO-1998005226-A9 | METHOD OF TREATING TOBACCO TO REDUCE NITROSAMINE CONTENT, AND PRODUCTS PRODUCED THEREBY | — | 1998-07-02 | — | — | WO | disclosed |
| WO-1998005226-A1 | METHOD OF TREATING TOBACCO TO REDUCE NITROSAMINE CONTENT, AND PRODUCTS PRODUCED THEREBY | WILLIAMS JONNIE R (US) | 1998-02-12 | — | — | WO | disclosed |
| US-5691365-A | Nicotinic receptor antagonists in the treatment of neuropharmacological disorders | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 1997-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240066019-A1 | COMPOSITION FOR ENHANCING MITOCHONDRIAL FUNCTION | MCU, SHMT2, CS | CHRNB2 259/4885CHRNA4 286/4885ALDH1A1 2008/4885 |
| US-20230087789-A1 | COMPOSITION FOR ENHANCING MITOCHONDRIAL FUNCTION | NLN, NDUFAB1, MT-ND2 | CHRNB2 202/4885CHRNA4 216/4885ALDH1A1 3131/4885 |
| US-11826362-B2 | Composition for enhancing mitochondrial function | NLN, NDUFAB1, MT-ND2 | CHRNB2 202/4885CHRNA4 216/4885ALDH1A1 3131/4885 |
| US-20230181557-A1 | COMPOSITIONS FOR SYNERGISTICALLY ENHANCING MITOCHONDRIAL FUNCTION | NLN, NME4, MT-ND2 | CHRNB2 193/4885CHRNA4 194/4885ALDH1A1 3121/4885 |
| US-11571415-B2 | Composition for enhancing mitochondrial function | SLC25A20, NLN, PC | CHRNB2 271/4885CHRNA4 268/4885ALDH1A1 1702/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.