Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7339913 | 0.94 | SMN1; SMN2 (0.47) | TSHRSMN1; SMN2GAARECQLKDM4E | |
| SCHEMBL7333761 | 0.87 | GAA (0.42) | TSHRSMN1; SMN2GAARECQLKDM4E | |
| SCHEMBL7331383 | 0.84 | KDM4E (0.62) | TSHRSMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL6577045 | 0.78 | RAB9A (0.52) | TSHRSMN1; SMN2GAARECQLKDM4E | |
| SCHEMBL11669735 | 0.73 | TSHR (0.56) | TSHRSMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL7331180 | 0.70 | GAA (0.63) | TSHRGAAKDM4EALDH1A1HPGD | |
| SCHEMBL28166988 | 0.70 | ALDH1A1 (0.50) | TSHRSMN1; SMN2GAAKDM4EALDH1A1 | |
| SCHEMBL2090928 | 0.70 | ALDH1A1 (0.62) | SMN1; SMN2GAAKDM4EALDH1A1HPGD | |
| SCHEMBL4440051 | 0.69 | ALDH1A1 (0.57) | TSHRSMN1; SMN2GAAKDM4EALDH1A1 | |
| SCHEMBL11669017 | 0.69 | TSHR (0.51) | TSHRSMN1; SMN2KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652237-A | 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes | WARNER-LAMBERT COMPANY (US) | 1997-07-29 | — | — | US | disclosed |