SCHEMBL8899384

SCHEMBL8899384

CN(C)C(C)(Cc1ccc(Br)cc1)C(=O)c1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR52 Q9Y2T5 1/20 0.40
PDPK1 O15530 1/20 0.40
OPRM1 P35372 1/20 0.39
OPRD1 P41143 1/20 0.39
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
TMEM97 Q5BJF2 1/20 0.38
SIGMAR1 Q99720 1/20 0.38
L3MBTL1 Q9Y468 3/20 0.38
TSHR P16473 1/20 0.38
HTT P42858 1/20 0.38
PTPN1 P18031 1/20 0.37
HPGD P15428 2/20 0.37
RAB9A P51151 2/20 0.37
NPC1 O15118 1/20 0.37
KDM4E B2RXH2 2/20 0.37
ALDH1A1 P00352 2/20 0.37
MAPT P10636 2/20 0.37
HDAC1 Q13547 1/20 0.37
HDAC6 Q9UBN7 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8899299 0.89 KMT2A (0.42) OPRM1OPRD1MEN1KMT2ATSHR
SCHEMBL8898280 0.87 NPC1 (0.44) MEN1KMT2AL3MBTL1PTPN1HPGD
SCHEMBL3322033 0.87 HPGD (0.47) L3MBTL1HTTHPGDRAB9ANPC1
SCHEMBL8897074 0.85 TDP1 (0.43) MEN1KMT2ATSHRPTPN1HPGD
SCHEMBL8896901 0.85 PPARG (0.46) PDPK1MEN1KMT2ATMEM97SIGMAR1
SCHEMBL8897900 0.84 HPGD (0.47) HPGDRAB9ANPC1ALDH1A1SMN1; SMN2
SCHEMBL8898784 0.83 EPHX2 (0.41) MEN1KMT2AL3MBTL1TSHRHPGD
SCHEMBL8898504 0.83 ACHE (0.50) MEN1KMT2AL3MBTL1RAB9ANPC1
SCHEMBL8898468 0.83 KMT2A (0.45) MEN1KMT2AL3MBTL1TSHRRAB9A
SCHEMBL8962004 0.81 KMT2A (0.50) MEN1KMT2AL3MBTL1HPGDRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5629356-A PHOTOCURABLE COMPOSITION CONTAINING ETHYLENICALLY UNSATURATED PHOTOPOLYMERIZABLE COMPOUND AND THE AMINOACETOPHENONE CIBA GEIGY CORPORATION (US) 1997-05-13 US disclosed
US-5554663-A α-aminoacetophenones as photoinitiators CIBA-GEIGY CORPORATION (US) 1996-09-10 US disclosed
US-5534629-A PHOTOPOLYMERIZATION OF PIGMENTED SYSTEMS, INKS CIBA-GEIGY CORPORATION (US) 1996-07-09 US disclosed
EP-0284561-B1 ALPHA-AMINOACETOPHENONES AS PHOTO INITIATORS CIBA-GEIGY AG (CH) 1993-05-12 EP disclosed
US-5077402-A For photocuring pigmented systems; printing inks, lacquers CIBA-GEIGY CORPORATION (US) 1991-12-31 US disclosed
EP-0284561-A2 Alpha-aminoacetophenones as photo initiators CIBA-GEIGY AG (CH) 1988-09-28 EP disclosed