Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL727707 | 0.67 | TDP1 (0.39) | TSHRTDP1CYP3A4ALDH1A1LMNA | |
| Biphenyl SCHEMBL2574161 | 0.65 | ALDH1A1 (0.82) | TSHRTDP1CYP3A4ALDH1A1CYP1A2 | |
| Hydrazine SCHEMBL912457 | 0.64 | TSHR (0.39) | TSHRTDP1CYP3A4ALDH1A1DPP4 | |
| Hydrazine SCHEMBL28164085 | 0.64 | CYP3A4 (0.86) | TSHRTDP1CYP3A4ALDH1A1DPP4 | |
| Phenol SCHEMBL673833 | 0.62 | TSHR (0.44) | TSHRTDP1CYP3A4ALDH1A1DPP4 | |
| Biphenyl SCHEMBL10613850 | 0.62 | ALDH1A1 (0.75) | TSHRTDP1CYP3A4ALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL411461 | 0.62 | — | — | |
| SCHEMBL29818354 | 0.62 | TDP1 (0.41) | TSHRTDP1CYP3A4ALDH1A1LMNA | |
| Aniline SCHEMBL9012788 | 0.62 | — | — | |
| Biphenyl SCHEMBL8817641 | 0.62 | ALDH1A1 (0.75) | TSHRTDP1CYP3A4ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111925659-A | Self-healing modified asphalt and preparation method and application thereof | 江苏宝利国际投资股份有限公司 | 2020-11-13 | — | — | CN | disclosed |
| US-5672630-A | MIXING WASTE RUBBER WITH UNVULCANIZED NEW RUBBER AND CHEMICAL DEVULCANIZING AGENT, KNEADING AND HEATING TO MASTICATE, VULCANIZING | KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) | 1997-09-30 | — | — | US | disclosed |
| EP-0744436-A1 | Process for producing reclaimed rubber or unvulcanized reclaimed rubber | KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) | 1996-11-27 | — | — | EP | disclosed |