Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 3/20 | 0.58 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 9/20 | 0.55 |
| ▸ | LMNA | P02545 | 7/20 | 0.55 |
| ▸ | TSHR | P16473 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | HTT | P42858 | 4/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8889796 | 0.90 | THRB (0.59) | THRBSIRT2MAPTLMNATSHR | |
| SCHEMBL8892213 | 0.84 | MAPT (0.58) | THRBMAPTLMNATSHRSMN1; SMN2 | |
| SCHEMBL8901320 | 0.83 | PDE4D (0.56) | THRBSIRT2MAPTLMNATSHR | |
| SCHEMBL8898881 | 0.78 | MAPT (0.58) | SIRT2MAPTLMNATSHRSMN1; SMN2 | |
| SCHEMBL8899857 | 0.75 | MAPT (0.58) | THRBMAPTLMNATSHRSMN1; SMN2 | |
| SCHEMBL12023614 | 0.72 | TSHR (0.79) | THRBSIRT2MAPTLMNATSHR | |
| SCHEMBL5717662 | 0.71 | TSHR (1.00) | SIRT2MAPTLMNATSHRSMN1; SMN2 | |
| SCHEMBL8899510 | 0.70 | SMN1; SMN2 (0.63) | THRBMAPTLMNATSHRSMN1; SMN2 | |
| SCHEMBL16712926 | 0.70 | POLB (0.49) | MAPTLMNASMN1; SMN2NPSR1L3MBTL1 | |
| SCHEMBL27429874 | 0.70 | TSHR (0.69) | SIRT2MAPTLMNATSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |