Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 3/20 | 0.59 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 10/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 8/20 | 0.54 |
| ▸ | TSHR | P16473 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8900255 | 0.90 | THRB (0.58) | THRBSIRT2MAPTTP53LMNA | |
| SCHEMBL8901320 | 0.84 | PDE4D (0.56) | THRBSIRT2MAPTTP53LMNA | |
| SCHEMBL8900709 | 0.80 | MAPT (0.63) | THRBMAPTTP53LMNATSHR | |
| SCHEMBL28816276 | 0.75 | SMPD1 (0.55) | THRBSIRT2MAPTTP53LMNA | |
| SCHEMBL8899857 | 0.74 | MAPT (0.58) | THRBMAPTTP53LMNATSHR | |
| SCHEMBL8892213 | 0.74 | MAPT (0.58) | THRBMAPTTP53LMNATSHR | |
| SCHEMBL8901439 | 0.74 | THRB (0.54) | THRBMAPTTP53LMNATSHR | |
| SCHEMBL12171483 | 0.74 | MAPT (0.67) | MAPTTP53LMNASMN1; SMN2MEN1 | |
| SCHEMBL25248790 | 0.73 | POLB (0.53) | THRBMAPTLMNATSHRSMN1; SMN2 | |
| SCHEMBL30506577 | 0.73 | POLB (0.53) | THRBMAPTLMNATSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |