SCHEMBL8900540

SCHEMBL8900540

CC(C)(C)OC(=O)NCc1cccc(CNS(=O)(=O)c2cccc3ccccc23)c1

nearest known ligand 0.53

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
NPY5R Q15761 3/20 0.53
CA12 O43570 1/20 0.50
CA1 P00915 1/20 0.50
CA7 P43166 1/20 0.50
CA14 Q9ULX7 1/20 0.50
KDM4A O75164 1/20 0.50
FABP4 P15090 1/20 0.48
GLS O94925 3/20 0.48
ACACB O00763 2/20 0.47
NQO2 P16083 1/20 0.47
BRD9 Q9H8M2 1/20 0.46
BAZ2B Q9UIF8 1/20 0.46
BAZ2A Q9UIF9 1/20 0.46
NSD2 O96028 2/20 0.45
TBXA2R P21731 1/20 0.45
CASP1 P29466 1/20 0.45
CYP19A1 P11511 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8891919 0.93 CA12 (0.52) NPY5RCA12CA1CA7CA14
SCHEMBL5665930 0.89 PRKD3 (0.52) NPY5R
SCHEMBL5662531 0.82 PRKD3 (0.54)
SCHEMBL29695254 0.81 NPY5R (0.58) NPY5RCA12CA1NQO2
SCHEMBL8900784 0.81 NPY5R (0.64) NPY5RCA12CA1NQO2
SCHEMBL8890347 0.81 NPY5R (0.64) NPY5RCA12CA1NQO2
SCHEMBL6039411 0.80 ACACB (0.69) NPY5RACACBTBXA2R
SCHEMBL6039406 0.80 ACACB (0.69) NPY5RACACBTBXA2R
SCHEMBL8890912 0.78 NPY5R (0.64) NPY5RCA1NSD2CYP19A1
SCHEMBL24300007 0.78 BRD4 (0.56) KDM4AGLSACACBNQO2BRD9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997020822-A1 QUINAZOLIN-2,4-DIAZIRINES AS NPY RECEPTOR ANTAGONIST NOVARTIS AG (CH) 1997-06-12 WO disclosed