Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8967406 | 0.97 | CHRNA7 (0.42) | MEN1KMT2ACHRNA7HRH3KDM1A | |
| SCHEMBL8541939 | 0.97 | CHRNA7 (0.42) | MEN1KMT2ACHRNA7HRH3KDM1A | |
| SCHEMBL8541943 | 0.97 | CHRNA7 (0.42) | MEN1KMT2ACHRNA7HRH3KDM1A | |
| SCHEMBL8546489 | 0.97 | CHRNA7 (0.42) | MEN1KMT2ACHRNA7HRH3KDM1A | |
| SCHEMBL9090924 | 0.90 | CHRNA7 (0.44) | MEN1KMT2ACHRNA7HRH3KDM1A | |
| SCHEMBL11190856 | 0.87 | CHRNA7 (0.42) | MEN1KMT2ACHRNA7HRH3KDM1A | |
| SCHEMBL11190854 | 0.87 | CHRNA7 (0.42) | MEN1KMT2ACHRNA7HRH3KDM1A | |
| Fumaric Acid SCHEMBL8545846 | 0.86 | MEN1 (0.41) | MEN1KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8967765 | 0.82 | CHRNA7 (0.46) | MEN1KMT2ACHRNA7KDM1ASLC6A2 | |
| SCHEMBL9010768 | 0.81 | CHRNA7 (0.42) | MEN1KMT2ACHRNA7KDM1ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5602167-A | 4-arylcyclohepta[c] pyrrole analgesics | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-02-11 | — | — | US | disclosed |
| US-5523412-A | AN UNSUBSTITUTED OR N-ALKYL- OR CYCLOALKYL-SUBSTITUTED PERHYDROCYCLOHEPTA(C)PYRROL-4-ONE | ORTHO PHARMACEUTICAL CORPORATION (US) | 1996-06-04 | — | — | US | disclosed |