Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | FPR2 | P25090 | 1/20 | 0.46 |
| ▸ | ACACB | O00763 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6461540 | 0.85 | LDHA (0.62) | LDHAKMT2AMMP1SLC6A4 | |
| SCHEMBL8902344 | 0.82 | LDHA (0.57) | LDHAHTTMMP1F2RL1SLC6A4 | |
| SCHEMBL11837761 | 0.81 | SRR (0.48) | HTT | |
| SCHEMBL28062779 | 0.78 | LDHA (0.53) | LDHAHTTMMP1F2RL1SLC6A4 | |
| SCHEMBL27535459 | 0.78 | LDHA (0.53) | LDHAHTTMMP1F2RL1SLC6A4 | |
| SCHEMBL11550992 | 0.77 | LDHA (0.56) | LDHAHTTF2RL1SLC6A4FPR2 | |
| SCHEMBL5672844 | 0.77 | LDHA (0.59) | LDHAHTTF2RL1SLC6A4FPR2 | |
| SCHEMBL28495195 | 0.75 | LDHA (0.61) | LDHAHTTF2RL1SLC6A4FPR2 | |
| SCHEMBL7517684 | 0.75 | LDHA (0.71) | LDHAHTTKMT2ASLC6A4 | |
| SCHEMBL15312744 | 0.75 | LDHA (0.71) | LDHAHTTKMT2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686481-A | INDOLE DERIVATIVES; TREATING HYPERTENSION, RENAL FAILURE, CEREBROVASCULAR DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1997-11-11 | — | — | US | disclosed |
| EP-0676959-A4 | ENDOTHELIN RECEPTOR ANTAGONISTS. | SMITHKLINE BEECHAM CORP (US) | 1996-01-03 | — | — | EP | disclosed |
| EP-0676959-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-10-18 | — | — | EP | disclosed |
| WO-1994014434-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-07-07 | — | — | WO | disclosed |