Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.35 |
| ▸ | HTR1A | P08908 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8441289 | 0.81 | KDM4E (0.50) | DRD2HTR1AKDM4EMEN1KMT2A | |
| SCHEMBL8443999 | 0.77 | SIGMAR1 (0.43) | KDM4EMEN1KMT2AHTR2ASIGMAR1 | |
| SCHEMBL9387302 | 0.70 | SIGMAR1 (0.46) | DRD2HTR1AKDM4EMEN1KMT2A | |
| SCHEMBL8444407 | 0.69 | TACR1 (0.48) | DRD2HTR1AKDM4EMEN1KMT2A | |
| SCHEMBL5230745 | 0.68 | KDM4E (0.46) | DRD2HTR1AKDM4EMEN1KMT2A | |
| SCHEMBL7948775 | 0.67 | SIGMAR1 (0.48) | DRD2HTR1AKDM4EMEN1KMT2A | |
| SCHEMBL28895871 | 0.66 | HDAC4 (0.54) | DRD2HTR1AKDM4EMEN1KMT2A | |
| SCHEMBL8441977 | 0.66 | SIGMAR1 (0.42) | KDM4EHTR2ASLC6A4SIGMAR1HTT | |
| SCHEMBL10616944 | 0.66 | APOBEC3A (0.48) | DRD2HTR1AKDM4EMEN1KMT2A | |
| SCHEMBL28895926 | 0.66 | TACR1 (0.44) | DRD2HTR1AKDM4EHTR2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997017337-A1 | SUBSTITUTED 1-INDOLYLPROPYL-4-BENZYL-TETRAHYDROPYRIDINE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1997-05-15 | — | — | WO | disclosed |