Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.44 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | FDPS | P14324 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethyl 3-(2,4-Dichlorophenyl)Acrylate SCHEMBL1895653 | 0.88 | MAPT (0.58) | TTRDPP4CA12CA1CA2 | |
| Ethyl 3-(2,4-Dichlorophenyl)Acrylate SCHEMBL1895655 | 0.88 | MAPT (0.58) | TTRDPP4CA12CA1CA2 | |
| SCHEMBL2393206 | 0.87 | BACE1 (0.63) | TTRDPP4CA12CA1CA2 | |
| SCHEMBL28754820 | 0.87 | BACE1 (0.63) | TTRDPP4CA12CA1CA2 | |
| SCHEMBL29372443 | 0.87 | BACE1 (0.63) | TTRDPP4CA12CA1CA2 | |
| SCHEMBL3019727 | 0.85 | TTR (0.47) | TTRDPP4CA12CA1CA2 | |
| SCHEMBL3019724 | 0.85 | TTR (0.47) | TTRDPP4CA12CA1CA2 | |
| SCHEMBL1508503 | 0.84 | ESR1 (0.60) | TTRDPP4CA12CA1CA2 | |
| SCHEMBL28594638 | 0.84 | ESR1 (0.60) | TTRDPP4CA12CA1CA2 | |
| SCHEMBL14926720 | 0.84 | MAPT (0.50) | TTRCA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0759026-A1 | AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-02-26 | — | — | EP | disclosed |
| WO-1995030645-A1 | AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-11-16 | — | — | WO | disclosed |