Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | CNKSR1 | Q969H4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3019724 | 1.00 | TTR (0.47) | TTRDPP4CA12CA1CA2 | |
| SCHEMBL4678281 | 0.89 | TTR (0.47) | TTRDPP4CA12CA1CA2 | |
| SCHEMBL4678277 | 0.89 | TTR (0.47) | TTRDPP4CA12CA1CA2 | |
| SCHEMBL3629095 | 0.85 | ESR1 (0.57) | TTRDPP4CA12CA1CA2 | |
| SCHEMBL27418956 | 0.85 | TTR (0.49) | TTRDPP4CA12CA1CA2 | |
| SCHEMBL8901318 | 0.85 | TTR (0.49) | TTRDPP4CA12CA1CA2 | |
| SCHEMBL10639238 | 0.85 | ESR1 (0.57) | TTRDPP4CA12CA1CA2 | |
| Ethyl 3-(2,4-Dichlorophenyl)Acrylate SCHEMBL1895655 | 0.85 | MAPT (0.58) | TTRDPP4CA12CA1CA2 | |
| Ethyl 3-(2,4-Dichlorophenyl)Acrylate SCHEMBL1895653 | 0.85 | MAPT (0.58) | TTRDPP4CA12CA1CA2 | |
| SCHEMBL2393206 | 0.84 | BACE1 (0.63) | TTRDPP4CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7855300-B2 | Bis(trimethylsilyl)phenyl compound or salt thereof, and use thereof | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2010-12-21 | — | — | US | disclosed |
| CN-101821274-A | Bis(trimethylsilyl)phenyl compound or salt thereof, and use thereof | TAIHO PHARMACEUTICAL CO LTD | 2010-09-01 | — | — | CN | disclosed |
| US-20100210591-A1 | BIS(TRIMETHYLSILYL)PHENYL COMPOUND OR SALT THEREOF, AND USE THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2010-08-19 | — | — | US | disclosed |
| EP-2202235-A1 | BIS(TRIMETHYLSILYL)PHENYL COMPOUND OR SALT THEREOF, AND USE THEREOF | Taiho Pharmaceutical Co., Ltd. (JP) | 2010-06-30 | — | — | EP | disclosed |
| EP-0134337-B1 | SUBSTITUTED 2,2-DIMETHYL-5-PHENOXYPENTANOIC ACID BENZAMIDES AND THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1988-01-07 | — | — | EP | disclosed |
| US-4554282-A | Substituted 2,2-dimethyl-5-phenoxypentanoic acid benzamides as anti-arteriosclerotic agents and method | WARNER-LAMBERT COMPANY (US) | 1985-11-19 | — | — | US | disclosed |
| EP-0134337-A1 | Substituted 2,2-dimethyl-5-phenoxypentanoic acid benzamides and their production | WARNER-LAMBERT COMPANY (US) | 1985-03-20 | — | — | EP | disclosed |
| US-4413011-A | Substituted 2,2-dimethyl-5-phenoxypentanoic acid benzamides as anti-arteriosclerotic agents and method | WARNER-LAMBERT COMPANY (US) | 1983-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210591-A1 | BIS(TRIMETHYLSILYL)PHENYL COMPOUND OR SALT THEREOF, AND USE THEREOF | RARA, RARB, RXRA | TTR 3924/4885DPP4 4369/4885CA12 1165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.