SCHEMBL14926720

SCHEMBL14926720

COC(=O)/C=C/c1ccc(C)cc1Cl

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.50
ALDH1A1 P00352 4/20 0.50
MEN1 O00255 4/20 0.50
KMT2A Q03164 4/20 0.50
KDM4E B2RXH2 3/20 0.50
CYP1A2 P05177 2/20 0.50
HPGD P15428 2/20 0.50
CYP2C19 P33261 2/20 0.50
TP53 P04637 1/20 0.50
CYP2C9 P11712 1/20 0.50
ALOX15 P16050 1/20 0.50
HSD17B10 Q99714 1/20 0.50
BACE1 P56817 1/20 0.47
MAOB P27338 1/20 0.46
GAA P10253 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
NPC1 O15118 1/20 0.44
CYP2D6 P10635 1/20 0.44
CASP3 P42574 1/20 0.44
RAB9A P51151 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18353123 0.87 ALDH1A1 (0.50) MAPTALDH1A1MEN1KMT2AKDM4E
SCHEMBL3532294 0.85 ALDH1A1 (0.51) MAPTALDH1A1MEN1KMT2AKDM4E
Methyl 3-(2,4-Dichlorophenyl)Acrylate SCHEMBL6315070 0.85 MAPT (0.62) MAPTALDH1A1MEN1KMT2AKDM4E
Methyl 3-(2,4-Dichlorophenyl)Acrylate SCHEMBL7434845 0.85 MAPT (0.62) MAPTALDH1A1MEN1KMT2AKDM4E
SCHEMBL3532296 0.85 ALDH1A1 (0.51) MAPTALDH1A1MEN1KMT2AKDM4E
SCHEMBL8901318 0.84 TTR (0.49) MAPTALDH1A1MEN1KMT2ABACE1
SCHEMBL1745374 0.84 BACE1 (0.69) MAPTALDH1A1MEN1KMT2AKDM4E
SCHEMBL5542490 0.83 MAPT (0.53) MAPTALDH1A1MEN1KMT2AKDM4E
SCHEMBL6505316 0.83 MAPT (0.53) MAPTALDH1A1MEN1KMT2AKDM4E
SCHEMBL11703114 0.83 ALDH1A1 (0.58) MAPTALDH1A1MEN1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9340634-B2 Polymer for use in liquid crystal alignment layer DIC CORPORATION (JP) 2016-05-17 US disclosed
US-9340634-B2 Polymer for use in liquid crystal alignment layer DIC CORPORATION (JP) 2016-05-17 US disclosed
US-20130116396-A1 POLYMER FOR USE IN LIQUID CRYSTAL ALIGNMENT LAYER DIC CORPORATION (JP) 2013-05-09 US disclosed
US-20130116396-A1 POLYMER FOR USE IN LIQUID CRYSTAL ALIGNMENT LAYER DIC CORPORATION (JP) 2013-05-09 US disclosed