Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 11/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.57 |
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | TP53 | P04637 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.55 |
| ▸ | RELA | Q04206 | 2/20 | 0.55 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8898716 | 0.90 | NPC1 (0.60) | TPH1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL8889557 | 0.89 | MAPT (0.65) | TPH1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL8899510 | 0.89 | SMN1; SMN2 (0.63) | MAPTSMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL1430356 | 0.83 | NR1H4 (0.73) | TPH1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL6248458 | 0.81 | LMNA (0.68) | SMN1; SMN2RAB9AKDM4EALDH1A1HTT | |
| SCHEMBL12171135 | 0.81 | SMN1; SMN2 (0.70) | MAPTSMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL8901131 | 0.81 | MAPT (0.62) | TPH1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL1430178 | 0.80 | NR1H4 (0.68) | MAPTSMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL8900709 | 0.79 | MAPT (0.63) | MAPTSMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL8890753 | 0.78 | MAPT (0.68) | MAPTTP53MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |