Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | PPID | Q08752 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6292622 | 0.83 | RARB (0.40) | GAAKMT2ALMNATSHRMEN1 | |
| SCHEMBL6366888 | 0.78 | GAA (0.44) | GAA | |
| SCHEMBL8635948 | 0.77 | RARB (0.44) | GAAALDH1A1KMT2ALMNAMEN1 | |
| SCHEMBL8561429 | 0.77 | RARB (0.44) | GAAALDH1A1KMT2ALMNAMEN1 | |
| SCHEMBL6298088 | 0.77 | MAPT (0.43) | GAAALDH1A1KMT2AL3MBTL1LMNA | |
| SCHEMBL6705228 | 0.77 | MAPT (0.43) | GAAALDH1A1KMT2AL3MBTL1LMNA | |
| SCHEMBL9295878 | 0.77 | OPRM1 (0.43) | ALDH1A1LMNATSHRKCNH2MAPT | |
| SCHEMBL6293871 | 0.76 | RARB (0.67) | ALDH1A1LMNACYP1A2 | |
| SCHEMBL6293872 | 0.76 | RARB (0.67) | ALDH1A1LMNACYP1A2 | |
| SCHEMBL9058220 | 0.76 | RARB (0.65) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997048672-A2 | SUBSTITUTED TETRAHYDRONAPHTHALENE AND DIHYDRONAPHTHALENE DERIVATIVES HAVING RETINOID AND/OR RETINOID ANTAGONIST-LIKE BIOLOGICAL ACTIVITY | ALLERGAN SALES, INC. (US) | 1997-12-24 | — | — | WO | disclosed |