Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | IDE | P14735 | 1/20 | 0.40 |
| ▸ | MYC | P01106 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 8/20 | 0.36 |
| ▸ | RXRG | P48443 | 6/20 | 0.36 |
| ▸ | RXRB | P28702 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6298088 | 1.00 | MAPT (0.43) | MAPTMEN1KMT2AGAANPSR1 | |
| SCHEMBL7639547 | 0.87 | RXRA (0.39) | GAARXRARXRGRXRBHNF4A | |
| SCHEMBL7639556 | 0.87 | RXRA (0.39) | GAARXRARXRGRXRBHNF4A | |
| SCHEMBL8644410 | 0.85 | RXRA (0.46) | NPSR1RXRARXRGRXRBALDH1A1 | |
| SCHEMBL6297429 | 0.81 | MAPT (0.46) | MAPTMEN1KMT2ARXRARXRG | |
| SCHEMBL6297432 | 0.81 | MAPT (0.46) | MAPTMEN1KMT2ARXRARXRG | |
| SCHEMBL8901599 | 0.77 | GAA (0.47) | MAPTMEN1KMT2AGAAL3MBTL1 | |
| SCHEMBL6292622 | 0.74 | RARB (0.40) | MAPTMEN1KMT2AGAANPSR1 | |
| SCHEMBL9058220 | 0.73 | RARB (0.65) | RXRARXRGRXRBRARBRARG | |
| SCHEMBL6293872 | 0.72 | RARB (0.67) | NPSR1RXRARXRGRXRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127469-A1 | Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity | JOHNSON ALAN T (US) | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127469-A1 | Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity | RARB, RARA, RXRB | MAPT 4431/4885MEN1 2555/4885KMT2A 3255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.