Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 0.67 |
| ▸ | BACE1 | P56817 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8904372 | 0.92 | REN (0.61) | REN | |
| SCHEMBL11039111 | 0.89 | REN (0.55) | RENBACE1 | |
| SCHEMBL7360546 | 0.89 | REN (0.72) | REN | |
| SCHEMBL7371160 | 0.89 | REN (0.64) | REN | |
| SCHEMBL10521833 | 0.88 | REN (0.58) | REN | |
| SCHEMBL11037229 | 0.88 | REN (0.67) | REN | |
| SCHEMBL8894149 | 0.88 | REN (0.62) | REN | |
| SCHEMBL8896012 | 0.88 | REN (0.62) | REN | |
| SCHEMBL10800861 | 0.85 | REN (0.59) | REN | |
| SCHEMBL10630607 | 0.85 | REN (0.67) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0081783-B1 | RENIN INHIBITORY PEPTIDES HAVING PHE 13 DELETION | MERCK & CO. INC. (US) | 1985-06-19 | — | — | EP | claimed |
| US-4479941-A | TREATMENT OF HYPERTENSION AND HYPERALDOSTERONISM | MERCK & CO., INC. (US) | 1984-10-30 | — | — | US | claimed |
| US-5688770-A | RENIN INHIBITOR AND BETA ADRENERGIC BLOCKING AGENT | SCHERING CORPORATION (US) | 1997-11-18 | — | — | US | disclosed |
| US-5352666-A | Using a renin inhibitor | SCHERING CORPORATION (US) | 1994-10-04 | — | — | US | disclosed |
| WO-1992013564-A1 | COMBINATION OF AN ANGIOTENSIN II ANTAGONIST OR RENIN INHIBITOR WITH A NEUTRAL ENDOPEPTIDASE INHIBITOR | SCHERING CORPORATION (US) | 1992-08-20 | — | — | WO | disclosed |
| EP-0498361-A2 | Combination of an angiotensin II antagonist or renin inhibitor with a neutral endopeptidase inhibitor | SCHERING CORPORATION (US) | 1992-08-12 | — | — | EP | disclosed |
| US-4906613-A | Antiglaucoma compositions and methods | SCHERING CORPORATION (US) | 1990-03-06 | — | — | US | disclosed |
| EP-0246381-A1 | Renin inhibitors and methods for using same | SCHERING CORPORATION (US) | 1987-11-25 | — | — | EP | disclosed |
| EP-0243477-A1 | RENIN INHIBITORS AND METHODS FOR USING SAME | SCHERING CORPORATION (US) | 1987-11-04 | — | — | EP | disclosed |
| WO-1987002581-A1 | RENIN INHIBITORS AND METHODS FOR USING SAME | SCHERING CORPORATION (US) | 1987-05-07 | — | — | WO | disclosed |
| US-4479941-A | TREATMENT OF HYPERTENSION AND HYPERALDOSTERONISM | MERCK & CO., INC. (US) | 1984-10-30 | — | — | US | disclosed |