Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | BACE1 | P56817 | 1/20 | 0.55 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4242416 | 0.89 | POLB (0.62) | POLBKDM4EACHEBACE1GRM4 | |
| SCHEMBL4249816 | 0.85 | POLB (0.58) | POLBKDM4EACHEBACE1GRM4 | |
| SCHEMBL4244832 | 0.83 | POLB (0.63) | POLBKDM4EACHEBACE1GRM4 | |
| SCHEMBL4238232 | 0.82 | POLB (0.62) | POLBKDM4EGRM4HPGDMAPT | |
| SCHEMBL29130900 | 0.81 | POLB (0.64) | POLBACHEBACE1GRM4HPGD | |
| SCHEMBL1162352 | 0.80 | TDP1 (0.56) | POLBKDM4EHPGDMAPTALDH1A1 | |
| SCHEMBL10105366 | 0.80 | ALDH1A1 (0.56) | POLBKDM4EHPGDMAPTALDH1A1 | |
| SCHEMBL4242005 | 0.80 | GRM4 (0.59) | POLBACHEBACE1GRM4MAPT | |
| SCHEMBL4242042 | 0.79 | GRM4 (0.61) | POLBKDM4EGRM4HPGDMAPT | |
| SCHEMBL22000031 | 0.78 | POLB (0.64) | POLBKDM4EACHEBACE1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686482-A | DOPAMINE RECEPTOR ANTAGONIST | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1997-11-11 | — | — | US | disclosed |
| EP-0757985-A1 | N-(3-PYRROLIDINYL)BENZAMIDE DERIVATIVE | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1997-02-12 | — | — | EP | disclosed |