Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.49 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8899897 | 0.92 | MRGPRX4 (0.57) | MAPTSMN1; SMN2SMPD1POLBGAA | |
| SCHEMBL8899650 | 0.83 | PDE4D (0.60) | MAPTSMN1; SMN2SMPD1POLBGAA | |
| SCHEMBL8899587 | 0.82 | MAPT (0.51) | MAPTSMN1; SMN2POLBGAAL3MBTL1 | |
| SCHEMBL8892213 | 0.81 | MAPT (0.58) | MAPTSMN1; SMN2SMPD1L3MBTL1MEN1 | |
| SCHEMBL25202091 | 0.77 | MAPT (0.58) | MAPTSMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL8899857 | 0.72 | MAPT (0.58) | MAPTSMN1; SMN2SMPD1L3MBTL1MEN1 | |
| SCHEMBL2090476 | 0.72 | KMT2A (0.57) | MAPTSMN1; SMN2POLBGAAL3MBTL1 | |
| SCHEMBL8890866 | 0.71 | NOTUM (0.74) | MAPTSMN1; SMN2POLBGAAL3MBTL1 | |
| SCHEMBL2359911 | 0.71 | MAPT (0.51) | MAPTSMN1; SMN2POLBGAAUSP2 | |
| SCHEMBL16712926 | 0.70 | POLB (0.49) | MAPTSMN1; SMN2SMPD1POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |