Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 5/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.59 |
| ▸ | PDE4A | P27815 | 3/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.59 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.58 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8890634 | 0.84 | PDE4D (0.60) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8901937 | 0.83 | MAPT (0.55) | SMPD1MAPTSMN1; SMN2POLBGAA | |
| SCHEMBL8899897 | 0.83 | MRGPRX4 (0.57) | SMPD1MAPTSMN1; SMN2POLBGAA | |
| SCHEMBL8889628 | 0.78 | PDE4D (0.61) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8900252 | 0.78 | PDE4D (0.65) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8889614 | 0.77 | PDE4D (0.73) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8888686 | 0.77 | PDE4D (0.73) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL15270505 | 0.77 | PDE4D (1.00) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL985307 | 0.76 | PDE4B (0.82) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL6878175 | 0.76 | PDE4B (0.85) | PDE4DPDE4BPDE4APDE4CCYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | claimed |
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |