Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044759 | 1.00 | LSS (0.48) | LSSLMNASMN1; SMN2NR4A2ALDH1A1 | |
| SCHEMBL7685521 | 0.86 | LSS (0.62) | LSSLMNANPSR1MAOBMEN1 | |
| SCHEMBL7685512 | 0.86 | LSS (0.62) | LSSLMNANPSR1MAOBMEN1 | |
| SCHEMBL9360157 | 0.86 | GAA (0.55) | LSSLMNASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL9360152 | 0.86 | GAA (0.55) | LSSLMNASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL8903155 | 0.85 | LSS (0.48) | LSSLMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL8903149 | 0.85 | LSS (0.48) | LSSLMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL8047698 | 0.84 | SRD5A2 (0.47) | LSSALDH1A1MAOBPTPN1 | |
| SCHEMBL8902485 | 0.84 | SRD5A2 (0.47) | LSSALDH1A1MAOBPTPN1 | |
| SCHEMBL8905081 | 0.82 | ALDH1A1 (0.49) | LSSALDH1A1PARP10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5637771-A | Compound useful for lowering cholesterol | HOFFMANN-LA ROCHE INC. (US) | 1997-06-10 | — | — | US | disclosed |
| US-5574071-A | ADMINISTERING PHENYLALKYLAMINO KETONES | HOFFMANN-LA ROCHE INC. (US) | 1996-11-12 | — | — | US | disclosed |
| US-5495048-A | ANTICHOLESTEROL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |