Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 13/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045167 | 1.00 | LSS (0.53) | LSSMEN1KMT2ASRD5A2PARP15 | |
| SCHEMBL7686037 | 0.86 | LSS (0.53) | LSSMEN1KMT2ALMNAMAPT | |
| SCHEMBL7686041 | 0.86 | LSS (0.53) | LSSMEN1KMT2ALMNAMAPT | |
| SCHEMBL8478986 | 0.84 | LSS (0.46) | LSSMEN1KMT2ASRD5A2LMNA | |
| SCHEMBL8478989 | 0.84 | LSS (0.46) | LSSMEN1KMT2ASRD5A2LMNA | |
| SCHEMBL7688254 | 0.83 | LSS (0.39) | LSSMEN1KMT2AMAPTMAPK1 | |
| SCHEMBL7688257 | 0.83 | LSS (0.39) | LSSMEN1KMT2AMAPTMAPK1 | |
| SCHEMBL7685512 | 0.83 | LSS (0.62) | LSSMEN1KMT2ASRD5A2LMNA | |
| SCHEMBL7685521 | 0.83 | LSS (0.62) | LSSMEN1KMT2ASRD5A2LMNA | |
| SCHEMBL7687942 | 0.82 | LSS (0.56) | LSSMEN1KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5637771-A | Compound useful for lowering cholesterol | HOFFMANN-LA ROCHE INC. (US) | 1997-06-10 | — | — | US | disclosed |
| US-5574071-A | ADMINISTERING PHENYLALKYLAMINO KETONES | HOFFMANN-LA ROCHE INC. (US) | 1996-11-12 | — | — | US | disclosed |
| US-5495048-A | ANTICHOLESTEROL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |