Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 13/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 12/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.41 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9566551 | 0.80 | HDAC1 (0.48) | HDAC1HDAC2HSP90AB1HSP90AA1HDAC6 | |
| SCHEMBL8904140 | 0.78 | HDAC1 (0.45) | HDAC1HDAC2HSP90AB1HSP90AA1HDAC6 | |
| SCHEMBL10996722 | 0.77 | HDAC1 (0.47) | HDAC1HDAC2HSP90AB1HSP90AA1HDAC6 | |
| SCHEMBL8708630 | 0.76 | HDAC1 (0.43) | HDAC1HDAC2HSP90AB1HSP90AA1HDAC6 | |
| SCHEMBL6272417 | 0.74 | ALDH1A1 (0.66) | HDAC1HDAC2HSP90AB1HSP90AA1HDAC6 | |
| SCHEMBL9369791 | 0.74 | HDAC1 (0.48) | HDAC1HDAC2HSP90AB1HSP90AA1HDAC6 | |
| SCHEMBL11729464 | 0.73 | HDAC1 (0.48) | HDAC1HDAC2HSP90AB1HSP90AA1HDAC6 | |
| SCHEMBL9776572 | 0.72 | HDAC6 (0.49) | HDAC1HDAC2HSP90AB1HSP90AA1HDAC6 | |
| SCHEMBL10510295 | 0.72 | HDAC1 (0.44) | HDAC1HDAC2HSP90AB1HSP90AA1HDAC6 | |
| SCHEMBL14916463 | 0.72 | HSP90AB1 (0.50) | HSP90AB1HSP90AA1HSP90B1TRAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0398231-B1 | Nucleoside analogs | ACAD OF SCIENCE CZECH REPUBLIC (CZ) | 1997-07-16 | — | — | EP | disclosed |
| EP-0398231-A2 | Nucleoside analogs | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CS) | 1990-11-22 | — | — | EP | disclosed |