Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 3/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.46 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.46 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4401959 | 0.82 | ALDH1A1 (0.54) | CYP2C19CYP1A2ALDH1A1POLBMAPT | |
| SCHEMBL15145494 | 0.80 | KMT2A (0.57) | ALDH1A1POLBTSHRKDM4EHPGD | |
| SCHEMBL1703110 | 0.79 | CYP2C19 (1.00) | CYP2C19CYP1A2ALDH1A1POLBMAPT | |
| SCHEMBL21664524 | 0.77 | CDYL (0.49) | CYP1A2CDYLHDAC3HDAC4HDAC1 | |
| SCHEMBL28545230 | 0.75 | TDP1 (0.53) | CYP2C19CYP1A2ALDH1A1MAPTKDM4E | |
| SCHEMBL890383 | 0.74 | CYP1A2 (0.70) | CYP2C19CYP1A2ALDH1A1POLBMAPT | |
| Phenanthrene SCHEMBL7967270 | 0.73 | PSMB8 (0.36) | CYP2C19CYP1A2ALDH1A1MAPTCYP2C9 | |
| SCHEMBL21363354 | 0.73 | ALDH1A1 (0.40) | CYP2C19CYP1A2ALDH1A1CHRM2CHRM4 | |
| SCHEMBL15684124 | 0.73 | CYP1A2 (0.68) | CYP2C19CYP1A2ALDH1A1POLBMAPT | |
| SCHEMBL30668502 | 0.73 | CYP1A2 (0.68) | CYP2C19CYP1A2ALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2860169-B1 | Method for obtaining novel derivatives of naphtalene for the in vivo diagnosis of Alzheimer's disease | CENTRO DE NEUROCIENCIAS DE CUBA (CU) | 2018-08-29 | — | — | EP | disclosed |
| US-20150217005-A1 | METHOD FOR OBTAINING NOVEL DERIVATIVES OF NAPHTHALENE FOR THE IN VIVO DIAGNOSIS OF ALZHEIMER'S DISEASE | SABLON CARRAZANA MARQUIZA (CU) | 2015-08-06 | — | — | US | disclosed |
| EP-2860169-A2 | Method for obtaining novel derivatives of naphtalene for the in vivo diagnosis of Alzheimer's disease | Centro De Neurociencias De Cuba (CU) | 2015-04-15 | — | — | EP | disclosed |
| US-20120321560-A1 | Method for Obtaining Novel Derivatives of Naphthalene for the In Vivo Diagnosis of Alzheimer's Disease | CENTRO DE NEUROCIENCIAS DE CUBA (CU) | 2012-12-20 | — | — | US | disclosed |
| EP-2436666-A2 | METHOD FOR OBTAINING NOVEL DERIVATIVES OF NAPHTALENE FOR THE IN VIVO DIAGNOSIS OF ALZHEIMER 'S DISEASE | Centro De Neurociencias De Cuba (CU) | 2012-04-04 | — | — | EP | disclosed |
| EP-2436666-A2 | METHOD FOR OBTAINING NOVEL DERIVATIVES OF NAPHTALENE FOR THE IN VIVO DIAGNOSIS OF ALZHEIMER 'S DISEASE | Centro De Neurociencias De Cuba (CU) | 2012-04-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120321560-A1 | Method for Obtaining Novel Derivatives of Naphthalene for the In Vivo Diagnosis of Alzheimer's Disease | SLC43A1, SLCO2B1, SLCO2A1 | CYP2C19 2874/4885CYP1A2 1183/4885ALDH1A1 1269/4885 |
| US-20150217005-A1 | METHOD FOR OBTAINING NOVEL DERIVATIVES OF NAPHTHALENE FOR THE IN VIVO DIAGNOSIS OF ALZHEIMER'S DISEASE | SLC43A1, SLCO2B1, FABP7 | CYP2C19 2927/4885CYP1A2 1126/4885ALDH1A1 1358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.