Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 3/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8904409 | 0.88 | TAAR1 (0.36) | TAAR1CTSBADRA2AADRA2BADRA2C | |
| SCHEMBL7451935 | 0.81 | TAAR1 (0.43) | TAAR1CYP2D6TSHRLMNAGLA | |
| SCHEMBL14908874 | 0.72 | TSHR (0.42) | TAAR1CYP2D6TSHRLMNAGLA | |
| SCHEMBL2693545 | 0.70 | CYP2D6 (0.36) | TAAR1CYP2D6TSHRCTSBPPARG | |
| SCHEMBL2872633 | 0.70 | TAAR1 (0.47) | TAAR1CYP2D6TSHRLMNAGLA | |
| SCHEMBL10925477 | 0.68 | EPHX1 (0.37) | TAAR1CYP2D6MAOB | |
| SCHEMBL10686536 | 0.68 | CYP1A2 (0.43) | CYP2D6PPARGPPARA | |
| SCHEMBL4442877 | 0.68 | TAAR1 (0.49) | TAAR1CYP2D6TSHRLMNAGLA | |
| SCHEMBL12011595 | 0.68 | NISCH (0.49) | TAAR1CYP2D6TSHRLMNAGLA | |
| SCHEMBL8903948 | 0.67 | YAP1 (0.36) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698706-A | BLOCKING TUMOR NECROSIS FACTOR | CHIROSCIENCE LIMITED (GB) | 1997-12-16 | — | — | US | disclosed |