Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 2/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8904379 | 0.88 | TAAR1 (0.35) | TAAR1ADRA2AADRA2BADRA2CCTSB | |
| SCHEMBL7451935 | 0.77 | TAAR1 (0.43) | TAAR1NPC1 | |
| SCHEMBL14909550 | 0.73 | MEN1 (0.43) | TAAR1ADRA2AADRA2BADRA2CPOLB | |
| SCHEMBL27530431 | 0.71 | CTSB (0.44) | MEN1KMT2AALDH1A1CTSB | |
| SCHEMBL8905078 | 0.71 | MAPT (0.37) | POLBMEN1KMT2AALDH1A1AAK1 | |
| SCHEMBL27984245 | 0.70 | TAAR1 (0.44) | TAAR1ADRA2AADRA2BADRA2CPOLB | |
| SCHEMBL5270550 | 0.70 | MEN1 (0.38) | TAAR1MEN1KMT2AALDH1A1CTSB | |
| SCHEMBL9563422 | 0.70 | MEN1 (0.38) | TAAR1MEN1KMT2AALDH1A1CTSB | |
| SCHEMBL7084380 | 0.69 | CTSB (0.40) | MEN1KMT2ACTSB | |
| SCHEMBL23890513 | 0.69 | ADRA2A (0.45) | ADRA2AADRA2BADRA2CPOLBS1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698706-A | BLOCKING TUMOR NECROSIS FACTOR | CHIROSCIENCE LIMITED (GB) | 1997-12-16 | — | — | US | disclosed |