Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9278163 | 0.91 | SMN1; SMN2 (0.73) | NOTUMPOLBTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL5492978 | 0.84 | SMN1; SMN2 (0.79) | NOTUMPOLBTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL5006023 | 0.83 | TSHR (0.75) | NOTUMPOLBTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL19041416 | 0.83 | ALDH1A1 (0.75) | NOTUMPOLBTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL8904589 | 0.80 | ALDH1A1 (0.65) | NOTUMPOLBTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL8904562 | 0.79 | SLC22A12 (0.52) | NOTUMPOLBTSHRALDH1A1HPGD | |
| SCHEMBL5360548 | 0.79 | NOTUM (0.70) | NOTUMPOLBTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL13041447 | 0.78 | TSHR (0.67) | NOTUMPOLBTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL14608503 | 0.78 | SMN1; SMN2 (0.64) | NOTUMPOLBTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL9394780 | 0.78 | SMN1; SMN2 (0.64) | NOTUMPOLBTSHRALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5616586-A | Tricyclic quinoxalinediones | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-04-01 | — | — | US | disclosed |
| EP-0642508-A1 | TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993008188-A1 | TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1993-04-29 | — | — | WO | disclosed |