Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.65 |
| ▸ | NPC1 | O15118 | 8/20 | 0.60 |
| ▸ | RAB9A | P51151 | 8/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9214372 | 0.92 | SMN1; SMN2 (0.68) | ALDH1A1NOTUMSMN1; SMN2POLBMAPT | |
| SCHEMBL2116912 | 0.86 | NPC1 (0.71) | ALDH1A1NOTUMNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29554766 | 0.86 | NPC1 (0.71) | ALDH1A1NOTUMNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10678854 | 0.85 | NOTUM (0.61) | ALDH1A1NOTUMNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10683148 | 0.81 | ALDH1A1 (0.67) | ALDH1A1NOTUMNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10683152 | 0.81 | ALDH1A1 (0.67) | ALDH1A1NOTUMNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8904564 | 0.81 | TUBB4A (0.52) | ALDH1A1NOTUMNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5492978 | 0.81 | SMN1; SMN2 (0.79) | ALDH1A1NOTUMNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8904584 | 0.80 | NOTUM (0.63) | ALDH1A1NOTUMNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5806132 | 0.79 | NOTUM (0.58) | ALDH1A1NOTUMNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5616586-A | Tricyclic quinoxalinediones | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-04-01 | — | — | US | disclosed |
| EP-0642508-A1 | TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993008188-A1 | TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1993-04-29 | — | — | WO | disclosed |