Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | REN | P00797 | 3/20 | 0.41 |
| ▸ | ACACB | O00763 | 2/20 | 0.37 |
| ▸ | EBP | Q15125 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8905139 | 1.00 | TSHR (0.47) | TSHRTP53RENACACBEBP | |
| SCHEMBL10667108 | 0.77 | TSHR (0.55) | TSHRTP53RENACACBEBP | |
| SCHEMBL11490630 | 0.76 | TRPA1 (0.47) | TSHRTP53SIGMAR1 | |
| SCHEMBL6381994 | 0.75 | TSHR (0.52) | TSHRTP53ACACBEBPSIGMAR1 | |
| SCHEMBL6044834 | 0.74 | TSHR (0.51) | TSHRTP53RENACACBEBP | |
| SCHEMBL6044829 | 0.74 | TSHR (0.51) | TSHRTP53RENACACBEBP | |
| SCHEMBL11479456 | 0.73 | SIGMAR1 (0.52) | TSHRTP53EBPSIGMAR1KCNH2 | |
| SCHEMBL547420 | 0.71 | TSHR (0.62) | TSHRTP53ACACBEBPSIGMAR1 | |
| SCHEMBL121893 | 0.71 | TSHR (0.48) | TSHRTP53SIGMAR1KCNH2BCHE | |
| SCHEMBL2281456 | 0.70 | TSHR (0.55) | TSHRTP53ACACBEBPSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5659065-A | CHEMICAL INTERMEDIATES FOR MEDICINAL ACTIVE AGENTS | NOVARTIS CORPORATION (US) | 1997-08-19 | — | — | US | disclosed |
| EP-0678500-A1 | Alpha-amino alkanoic acids and reduction products as intermediates in the preparation of renin inhibitors | CIBA-GEIGY AG (CH) | 1995-10-25 | — | — | EP | disclosed |