Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL6219162 | 1.00 | TYMS (0.41) | TYMSHSD17B10KDM4EMMP2THRB | |
| Phosphoric Acid SCHEMBL828102 | 1.00 | TYMS (0.41) | TYMSHSD17B10KDM4EMMP2THRB | |
| Phosphoric Acid SCHEMBL16567884 | 1.00 | TYMS (0.41) | TYMSHSD17B10KDM4EMMP2THRB | |
| Phosphoric Acid SCHEMBL16568053 | 1.00 | TYMS (0.41) | TYMSHSD17B10KDM4EMMP2THRB | |
| 1,4-Butanediol SCHEMBL27437351 | 0.92 | TYMS (0.41) | TYMSHSD17B10KDM4EMMP2THRB | |
| 1,4-Butanediol SCHEMBL28692 | 0.92 | TYMS (0.41) | TYMSHSD17B10KDM4EMMP2THRB | |
| Phosphoric Acid SCHEMBL9551052 | 0.88 | GPR84 (0.45) | TYMSHSD17B10KDM4EMMP2THRB | |
| Phosphoric Acid SCHEMBL28170316 | 0.88 | GPR84 (0.45) | TYMSHSD17B10KDM4EMMP2THRB | |
| 1,6-Hexanediol SCHEMBL20582374 | 0.88 | GPR84 (0.45) | TYMSHSD17B10KDM4EMMP2THRB | |
| 1,6-Hexanediol SCHEMBL27687126 | 0.88 | GPR84 (0.45) | TYMSHSD17B10KDM4EMMP2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105531381-B | It avoids generating the high molecular weight PCR product induced by poly A carrier using oligomer dT molecule | 霍夫曼-拉罗奇有限公司 | 2019-08-09 | — | — | CN | disclosed |
| US-9611505-B2 | Application of oligo-DT molecules to avoid generation of high molecular PCR products induced by poly-A carrier | ROCHE MOLECULAR SYSTEMS, INC. (US) | 2017-04-04 | — | — | US | disclosed |
| US-20150079600-A1 | Application of Oligo-DT Molecules To Avoid Generation of High Molecular PCR Products Induced By Poly-A Carrier | ROCHE DIAGNOSTICS GMBH (DE) | 2015-03-19 | — | — | US | disclosed |
| US-5646261-A | PHOSPHORUS DERIVATIZED; ANTISENSE AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-07-08 | — | — | US | disclosed |