SCHEMBL8905450

SCHEMBL8905450

CCCc1nc2ccc(N3CCCCC3=O)cc2n1-c1ccc(-c2ccccc2)c(C(=O)O)c1C

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PPARG P37231 9/20 0.37
PDE10A Q9Y233 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8905454 0.84 PPARG (0.42) PPARG
SCHEMBL8906972 0.84 AGTR1 (0.39)
SCHEMBL8907060 0.84 AGTR1 (0.39)
SCHEMBL8905662 0.84 AGTR1 (0.39)
SCHEMBL8905229 0.82 AGTR1 (0.36)
SCHEMBL8906397 0.81 BRD9 (0.36) PDE10A
SCHEMBL8906951 0.81 AGTR1 (0.39) PPARG
SCHEMBL8907059 0.81 POLB (0.38) PPARG
SCHEMBL8907575 0.80 LMNA (0.35)
SCHEMBL8907335 0.80 PPARG (0.39) PPARGPDE10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5684029-A HYPOTENSIVE AGENTS KARL THOMAE GMBH (DE) 1997-11-04 US disclosed