Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxypurinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH known ✓ | P47989 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | PI4KA | P42356 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.35 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxypurinol SCHEMBL5799552 | 0.96 | SMN1; SMN2 (0.37) | SMN1; SMN2XDHRETPI4KALRRK2 | |
| Oxypurinol SCHEMBL8905835 | 0.96 | SMN1; SMN2 (0.37) | SMN1; SMN2XDHRETPI4KALRRK2 | |
| Oxypurinol SCHEMBL8905886 | 0.96 | SMN1; SMN2 (0.37) | SMN1; SMN2XDHRETPI4KALRRK2 | |
| Oxypurinol SCHEMBL8905877 | 0.94 | SMN1; SMN2 (0.36) | SMN1; SMN2XDHRETPI4KALRRK2 | |
| Oxypurinol SCHEMBL9421598 | 0.87 | SMN1; SMN2 (0.36) | SMN1; SMN2XDHRETPI4KALRRK2 | |
| Oxypurinol SCHEMBL9421596 | 0.87 | JAK2 (0.40) | SMN1; SMN2XDHALDH1A1ADORA2ALMNA | |
| Oxypurinol SCHEMBL5800677 | 0.82 | SMN1; SMN2 (0.35) | SMN1; SMN2CDK2CYP1A2ALDH1A1LMNA | |
| SCHEMBL2266999 | 0.78 | PLK4 (0.45) | SMN1; SMN2XDHRETPI4KALRRK2 | |
| SCHEMBL1952036 | 0.78 | SMN1; SMN2 (0.36) | SMN1; SMN2XDHRETPI4KALRRK2 | |
| SCHEMBL7635298 | 0.78 | XDH (0.34) | SMN1; SMN2XDHRETPI4KALRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5661154-A | Oxypurinol alkali and alkaline earth salts in amorphorous or crystalline form as agents for treating hyperuricaemia and gout | HENNING BERLIN GMBH CHEMIE-UND PHARMAWERK (DE) | 1997-08-26 | — | — | US | disclosed |
| US-5484605-A | Agent for treating chronically inflammatory intestinal diseases | HENNING BERLIN GMBH CHEMIE-UND PHARMAWERK (DE) | 1996-01-16 | — | — | US | disclosed |
| US-5430037-A | Oxypurinol alkali and alkalane earth salts in amorphous or crystalline form as agents for treating hyperuricaemia and gout | HENNING BERLIN GMBH CHEMIE -UND PHARMAWERK (DE) | 1995-07-04 | — | — | US | disclosed |