Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 14/20 | 0.44 |
| ▸ | REN | P00797 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 4/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | CTSB | P07858 | 2/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8905697 | 1.00 | CTSK (0.44) | CTSKRENTP53TSHRATM | |
| SCHEMBL6044618 | 0.84 | TP53 (0.46) | CTSKRENTP53TSHRATM | |
| SCHEMBL6044811 | 0.84 | TP53 (0.46) | CTSKRENTP53TSHRATM | |
| SCHEMBL8905435 | 0.81 | CYP1A2 (0.45) | CTSKRENCTSSCTSLCTSB | |
| SCHEMBL8905431 | 0.81 | CYP1A2 (0.45) | CTSKRENCTSSCTSLCTSB | |
| SCHEMBL1519855 | 0.77 | PPARG (0.51) | CTSKATMCTSSCTSLCTSB | |
| SCHEMBL1519981 | 0.77 | PPARG (0.51) | CTSKATMCTSSCTSLCTSB | |
| SCHEMBL1519854 | 0.77 | PPARG (0.51) | CTSKATMCTSSCTSLCTSB | |
| SCHEMBL6044770 | 0.77 | REN (0.50) | REN | |
| SCHEMBL2400972 | 0.75 | CTSK (0.56) | CTSKATMCTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5659065-A | CHEMICAL INTERMEDIATES FOR MEDICINAL ACTIVE AGENTS | NOVARTIS CORPORATION (US) | 1997-08-19 | — | — | US | claimed |
| EP-0678500-A1 | Alpha-amino alkanoic acids and reduction products as intermediates in the preparation of renin inhibitors | CIBA-GEIGY AG (CH) | 1995-10-25 | — | — | EP | claimed |
| US-5659065-A | CHEMICAL INTERMEDIATES FOR MEDICINAL ACTIVE AGENTS | NOVARTIS CORPORATION (US) | 1997-08-19 | — | — | US | disclosed |
| EP-0678500-A1 | Alpha-amino alkanoic acids and reduction products as intermediates in the preparation of renin inhibitors | CIBA-GEIGY AG (CH) | 1995-10-25 | — | — | EP | disclosed |