Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 6/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 6/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 6/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 6/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5965355 | 0.84 | KMT2A (0.51) | KMT2AACEMEN1PDK1PDK2 | |
| SCHEMBL27548369 | 0.84 | KMT2A (0.51) | KMT2AACEMEN1PDK1PDK2 | |
| SCHEMBL5965361 | 0.84 | KMT2A (0.51) | KMT2AACEMEN1PDK1PDK2 | |
| SCHEMBL29443080 | 0.81 | KMT2A (0.46) | KMT2AACEMEN1DRD2DRD4 | |
| SCHEMBL21490396 | 0.81 | KMT2A (0.46) | KMT2AACEMEN1DRD2DRD4 | |
| SCHEMBL6193812 | 0.79 | POLB (0.52) | KMT2AACEMEN1TSHR | |
| SCHEMBL17559114 | 0.78 | MTNR1A (0.54) | KMT2AACEMEN1TSHRMTNR1A | |
| SCHEMBL27466432 | 0.78 | KMT2A (0.47) | KMT2AACEMEN1TSHRMTNR1A | |
| SCHEMBL27483252 | 0.78 | KMT2A (0.47) | KMT2AACEMEN1TSHRMTNR1A | |
| SCHEMBL6625409 | 0.77 | KMT2A (0.46) | KMT2AACEMEN1TSHRMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5616586-A | Tricyclic quinoxalinediones | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-04-01 | — | — | US | disclosed |
| EP-0642508-A1 | TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993008188-A1 | TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1993-04-29 | — | — | WO | disclosed |