Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 16/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8906253 | 1.00 | REN (0.46) | RENADRA1DADRA1AADRA1BSIGMAR1 | |
| SCHEMBL6044140 | 0.89 | REN (0.48) | REN | |
| SCHEMBL6045096 | 0.89 | REN (0.48) | REN | |
| SCHEMBL8905620 | 0.87 | KDM4E (0.51) | RENSIGMAR1 | |
| SCHEMBL8905614 | 0.87 | KDM4E (0.51) | RENSIGMAR1 | |
| SCHEMBL4300111 | 0.86 | REN (0.52) | REN | |
| SCHEMBL4300113 | 0.86 | REN (0.52) | REN | |
| SCHEMBL20577097 | 0.84 | SIGMAR1 (0.47) | RENADRA1DADRA1AADRA1BSIGMAR1 | |
| SCHEMBL20482623 | 0.83 | MEN1 (0.48) | RENADRA1DADRA1AADRA1B | |
| SCHEMBL13131318 | 0.79 | APP (0.48) | ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5659065-A | CHEMICAL INTERMEDIATES FOR MEDICINAL ACTIVE AGENTS | NOVARTIS CORPORATION (US) | 1997-08-19 | — | — | US | disclosed |
| EP-0678500-A1 | Alpha-amino alkanoic acids and reduction products as intermediates in the preparation of renin inhibitors | CIBA-GEIGY AG (CH) | 1995-10-25 | — | — | EP | disclosed |