Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4595897 | 0.78 | KMT2A (0.47) | MEN1KMT2ASMN1; SMN2LMNAP2RX1 | |
| Iodide SCHEMBL27570286 | 0.77 | KMT2A (0.46) | MEN1KMT2ASMN1; SMN2LMNAP2RX1 | |
| SCHEMBL31536053 | 0.74 | MEN1 (0.48) | MEN1KMT2ASMN1; SMN2LMNAP2RX4 | |
| Bromide SCHEMBL2027811 | 0.70 | MEN1 (0.41) | MEN1KMT2ASMN1; SMN2LMNAP2RX1 | |
| SCHEMBL28742796 | 0.69 | MEN1 (0.43) | MEN1KMT2ALMNAP2RX4MAPK1 | |
| SCHEMBL27542972 | 0.69 | MEN1 (0.43) | MEN1KMT2ALMNAP2RX4MAPK1 | |
| SCHEMBL30100361 | 0.69 | MEN1 (0.51) | MEN1KMT2ASMN1; SMN2LMNAP2RX1 | |
| SCHEMBL20651294 | 0.69 | MEN1 (0.51) | MEN1KMT2ASMN1; SMN2LMNAP2RX1 | |
| SCHEMBL4595683 | 0.69 | MEN1 (0.51) | MEN1KMT2ASMN1; SMN2LMNAP2RX1 | |
| Iodide SCHEMBL28149370 | 0.67 | MEN1 (0.50) | MEN1KMT2ASMN1; SMN2LMNAP2RX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691121-A | PHOTOGRAPHIC LIGHT-SENSITIVE SILVER HALIDE MATERIAL | AGFA-GEVAERT. N.V. (BE) | 1997-11-25 | — | — | US | disclosed |
| EP-0704751-A1 | Method for making negative lith images or direct positive images | AGFA-GEVAERT N.V. (BE) | 1996-04-03 | — | — | EP | disclosed |