Iodide

Iodide

SCHEMBL8906995

COC(=O)C=CCCCCC[Zn].I

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG

The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 2/20 0.43
KEAP1 Q14145 1/20 0.43
NFE2L2 Q16236 1/20 0.43
MAPT P10636 2/20 0.40
CNR1 P21554 3/20 0.39
CNR2 P34972 3/20 0.39
ALDH1A1 P00352 2/20 0.38
LMNA P02545 1/20 0.38
PSMB11 A5LHX3 1/20 0.35
PSMA7 O14818 1/20 0.35
PSMB1 P20618 1/20 0.35
PSMA1 P25786 1/20 0.35
PSMA2 P25787 1/20 0.35
PSMA3 P25788 1/20 0.35
PSMA4 P25789 1/20 0.35
PSMB8 P28062 1/20 0.35
PSMB9 P28065 1/20 0.35
PSMA5 P28066 1/20 0.35
PSMB4 P28070 1/20 0.35
PSMB6 P28072 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Iodide SCHEMBL8907661 0.98 HCAR2 (0.44) HCAR2KEAP1NFE2L2MAPTCNR1
Iodide SCHEMBL8906768 0.92 HCAR2 (0.46) HCAR2KEAP1NFE2L2MAPTCNR1
SCHEMBL9076476 0.90 HCAR2 (0.48) HCAR2KEAP1NFE2L2MAPTCNR1
SCHEMBL9076474 0.90 HCAR2 (0.48) HCAR2KEAP1NFE2L2MAPTCNR1
SCHEMBL29626440 0.88 HCAR2 (0.55) HCAR2KEAP1NFE2L2MAPTCNR1
SCHEMBL31681514 0.88 HCAR2 (0.55) HCAR2KEAP1NFE2L2MAPTCNR1
SCHEMBL29626505 0.82 HCAR2 (0.57) HCAR2KEAP1NFE2L2MAPTCNR1
SCHEMBL25405291 0.81 HCAR2 (0.46) HCAR2KEAP1NFE2L2MAPTCNR1
SCHEMBL21952141 0.81 MAPT (0.59) HCAR2KEAP1NFE2L2MAPTCNR1
SCHEMBL3710792 0.81 PPARG (0.51) MAPTCNR1CNR2LMNAPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5639899-A TREATMENT OF PERIPHERAL CIRCULATORY DISTURBANCES TAISHO PHARMACEUTICAL CO., LTD. (JP) 1997-06-17 US disclosed
EP-0597095-B1 PROSTAGLANDIN E1 ANALOGUE TAISHO PHARMACEUTICAL CO LTD (JP) 1996-10-30 EP disclosed
EP-0597095-A1 PROSTAGLANDIN E1 ANALOGUE TAISHO PHARMACEUTICAL CO. LTD (JP) 1994-05-18 EP disclosed